Review for Isle Casino - Cape Girardeau Review For Isle Casino - Cape Girardeau Google User Apr 5 '17 at 18:17 Friendly and helpful staff. This was the first casino I had ever gone to. Lots and lots of slots with a few tables in the center. Its a lot of fun just walking around and looking at all the machines. I lost about 20 dollars over the course of 3 hours but it was all in the fun of playing. Definatly will go back. View full site to comment or like